Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients
Abstract Background Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still remain unknown. Here, we report our find...
Main Authors: | Vasiliki Chondrou, Petros Kolovos, Argyro Sgourou, Alexandra Kourakli, Alexia Pavlidaki, Vlasia Kastrinou, Anne John, Argiris Symeonidis, Bassam R. Ali, Adamantia Papachatzopoulou, Theodora Katsila, George P. Patrinos |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-10-01
|
Series: | Human Genomics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40246-017-0120-8 |
Similar Items
-
Impact of ZBTB7A hypomethylation and expression patterns on treatment response to hydroxyurea
by: Vasiliki Chondrou, et al.
Published: (2018-10-01) -
Inhibition of VEGFA Increases the Sensitivity of Ovarian Cancer Cells to Chemotherapy by Suppressing VEGFA-Mediated Autophagy
by: Li X, et al.
Published: (2020-08-01) -
Vegfa Impacts Early Myocardium Development in Zebrafish
by: Diqi Zhu, et al.
Published: (2017-02-01) -
Role of Spongiotrophoblast VEGFA during Pregnancy
by: Li, Han
Published: (2012) -
Role of Spongiotrophoblast VEGFA during Pregnancy
by: Li, Han
Published: (2012)