Synthesis and Antimicrobial activity 2-chloro-6-methylquinoline Hydrazone derivatives

• Main Authors: Rajiv Kumar, Suresh Kumar, Sushma Drabu, Sandhya Bawa
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2009-12-01
• Series: Journal of Pharmacy and Bioallied Sciences
• Subjects: 2-Chloro-3-formyl-6-methylquinoline, hydrazones, antibacterial, antifungal activity
• Online Access: http://opubs.com/jpbs/index.php/jpbs/article/view/17
• ISSN: 0975-7406

<div>A series of 2-chloro-6-methylquinoline hydrazones (3a-o) were synthesized by the condensation of substituted acyl</div><div>hydrazines, semicarbazide, thiosemicarbazide and INH with 2-chloro-3-formyl-6-methylquinoline in absolute alcohol.</div><div>The structures of compounds were established using spectral data and elemental analysis. All the compounds were</div><div>evaluated for their antibacterial activity against Escherichia coli (NCTC, 10418), Staphylococcus aureus (NCTC, 65710)</div><div>and Pseudomonas aeruginosa (NCTC, 10662). Compounds were also tested for antifungal activity aganist Aspergillus</div><div>niger (MTCC, 281), Aspergillus flavus (MTCC, 277), Monascus purpureus (MTCC, 369) and Penicillium citrinum</div><div>(NCIM, 768) by cup-plate method.</div>