Coagulation FXIII-A Protein Expression Defines Three Novel Sub-populations in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia Characterized by Distinct Gene Expression Signatures

Coagulation FXIII-A Protein Expression Defines Three Novel Sub-populations in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia Characterized by Distinct Gene Expression Signatures

Background: Leukemic B-cell precursor (BCP) lymphoblasts were identified as a novel expression site for coagulation factor XIII subunit A (FXIII-A). Flow cytometry (FC) revealed three distinct expression patterns, i.e., FXIII-A negative, FXIII-A dim, and FXIII-A bright subgroups. The FXIII-A negativ...

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Bibliographic Details
Main Authors: Katalin Gyurina, Bettina Kárai, Anikó Ujfalusi, Zsuzsanna Hevessy, Gábor Barna, Pál Jáksó, Gyöngyi Pálfi-Mészáros, Szilárd Póliska, Beáta Scholtz, János Kappelmayer, Gábor Zahuczky, Csongor Kiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
pediatric BCP-ALL
FXIII-A
F13A1
gene expression signature
B-other genotype
oligonucleotide microarray
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01063/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01063/full

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