Anti-M: Report of two cases and review of literature

• Main Authors: Tondon Rashmi, Kataria Rahul, Chaudhry Rajendra
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2008-01-01
• Series: Asian Journal of Transfusion Science
• Subjects: Anti-M; immunizing; naturally occurring
• Online Access: http://www.ajts.org/article.asp?issn=0973-6247;year=2008;volume=2;issue=2;spage=81;epage=83;aulast=Tondon
• ISSN: 0973-6247; 1998-3565

Anti-M is a fairly common naturally occurring antibody with rarely causing hemolytic transfusion reactions or hemolytic disease of the newborn. Most anti-M are not active at 37^o C and can generally be ignored in transfusion practice. However, we did not find this antibody to be fairly common and detected only two cases of anti-M in the past three years. We describe these two cases; one ′immunizing′ type and other ′naturally occurring′ and review the literature. The immunizing type was reactive at 37^o C as well as AHG phase of testing with IgG component, and showing dosage effect while the other was ′naturally occurring′ reactive well below 37^o C. Though rare, sometimes these antibodies can be of clinical significance when the antibody detected is reactive at 37^o C and AHG phase. When the antibody is active at 37^o C, M antigen negative cross match compatible red cell unit should be given.