BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor

BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor

Chimeric antigen receptor (CAR) T cells are powerful in eradicating hematological malignancies, but their efficacy is limited in treating solid tumors. One of the barriers is the immunosuppressive response induced by immunomodulatory signaling pathways. Pharmacological targeting of these immunosuppr...

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Bibliographic Details
Main Authors: Jiaxing Tang, Yan Zou, Long Li, Fengping Lu, Hongtao Xu, Pengxuan Ren, Fang Bai, Gabriele Niedermann, Xuekai Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
chimeric antigen receptor
BAY 60-6583
solid tumor
immunotherapy
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.619800/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.619800/full

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