Analysis of Serum Leptin Levels in Skin Tag Patients

• Main Authors: Raja Nurhayati, Imam Budi Putra, Remenda Siregar
• Format: Article
• Language: English
• Published: DiscoverSys 2019-04-01
• Series: Bali Medical Journal
• Subjects: skin tag, serum leptin level, impaired lipid metabolism
• Online Access: https://balimedicaljournal.org/index.php/bmj/article/view/1352

<p><strong>Background :</strong> Skin tag is a benign tumor of the skin with papules, filiform or pedunculated clinical feature with soft consistency, skin-like to brownish colored and often arises in the flexure area. Etiopathogenesis of <em>skin tag</em> is still unclear, but one of the etiology is associated with leptin hormone. Increased levels of serum leptin level are expected occuring in patients with skin tag.</p><p><strong>Objective :</strong> To determine the differences between serum leptin levels in skin tag patients and controls.</p><p><strong>Subjects and method :</strong> This study is an analytic study with cross sectional design involving 33 subjects with <em>skin tag</em> and 33 healthy controls. Diagnosis of <em>skin tag </em>was made based on history and clinical examination, we conducted blood sampling and measurement of serum leptin level to the patients and controls.</p><p><strong>Results :</strong> In this study, we found the mean serum leptin levels of skin tag patients were highest on aged group 40-49 years (36.21 ± 10.03 ng/ml). The mean serum leptin level of female skin tag patients (36.98 ± 17.67 ng/ml) was higher compared to male (28.32 ± 12.04 ng/ml). The mean serum leptin level of skin tag patients with a family history (34.69 ± 12.77 ng/ml) was higher compared to patients without family history (20.30 ± 8.63 ng/ml). The mean serum leptin level in the skin tag group (29.89 ± 13.34 ng/ml) was higher compared to the control group (22.53 ± 12.91 ng/ml) with p = 0.034.</p><p><strong>Conclusion :</strong> There were significant differences in serum leptin levels between skin tag patients and control.</p>