HIV-1 protease inhibitory effects of some selected plants in Caesalpiniaceae and Papilionaceae families
Fifty-two ethanol and water extracts of the plants in Caesalpiniaceae and Papilionaceae families were screened for their HIV-1 protease (HIV-1 PR) inhibitory activities using high performance liquid chromatography (HPLC) technique. Among the tested extracts, Cassia garrettiana (wood, water extract)...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Prince of Songkla University
2003-07-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://www.sjst.psu.ac.th/journal/25-4-pdf/10caesalpiniaceae.pdf |
| Summary: | Fifty-two ethanol and water extracts of the plants in Caesalpiniaceae and Papilionaceae families were screened for their HIV-1 protease (HIV-1 PR) inhibitory activities using high performance liquid chromatography (HPLC) technique. Among the tested extracts, Cassia garrettiana (wood, water extract) showed the most potent inhibitory activity against HIV-1 PR, followed by Cassia garrettiana (wood, EtOH extract) and Caesalpinia sappan (wood, EtOH extract) with IC50 of 18, 32 and 75 μg/ml, respectively. The isolation of active substances against HIV-1 PR of these two plants will be further investigated. |
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| ISSN: | 0125-3395 |