Longitudinal Disease Detection Rates for the Evaluation of Disease Detection Technologies with Application in High-Risk Breast Cancer Screening
Context: This study presents a longitudinal simulation of disease screening at a variety of different test sensitivities. Aims: It is demonstrated that the difference between the performance of high quality tests and poor quality tests are relatively small in terms of the commonly used longitudi...
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3794/76-%205693_E(%20_%20)_F(H)_PF1(VH)_PFA(H)_PF1(PUH)_OLF.pdf |
| Summary: | Context: This study presents a longitudinal simulation of
disease screening at a variety of different test sensitivities.
Aims: It is demonstrated that the difference between the
performance of high quality tests and poor quality tests are
relatively small in terms of the commonly used longitudinally
measured disease detection rate.
Statistical Analysis: This simulation study is focused on the
screening of patients at high-risk for breast cancer and thus
used plausible rates of new cases of disease and initial disease
prevalence for this population.
Results and Conclusions: The effects of varying the rate at
which the disease enters the population and the initial disease
prevalence is also discussed and was determined to not affect
this study’s conclusions regarding the inappropriateness of the
use of the longitudinally measured disease detection rate for
the evaluation of screening technologies. |
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| ISSN: | 2249-782X 0973-709X |