Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome.

Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome.

Marfan syndrome (MFS) is an autosomal-dominant disorder of connective tissue caused by mutations in the fibrillin-1 (FBN1) gene. Mortality is often due to aortic dissection and rupture. We investigated the structural and functional properties of the heart and aorta in a [Fbn1C1039G/+] MFS mouse usin...

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Bibliographic Details
Main Authors: Ling Lee, Jason Z Cui, Michelle Cua, Mitra Esfandiarei, Xiaoye Sheng, Winsey Audrey Chui, Michael Haoying Xu, Marinko V Sarunic, Mirza Faisal Beg, Cornelius van Breemen, George G S Sandor, Glen F Tibbits
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5100915?pdf=render

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