The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph node biomechanics in immunity. We present experiment...

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Main Authors: Meghan J. O'Melia, Amanda W. Lund, Susan N. Thomas
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219304559
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spelling doaj-30300c4056f640c083bd303d3f2835bb2020-11-24T23:51:17ZengElsevieriScience2589-00422019-12-01222843The Biophysics of Lymphatic Transport: Engineering Tools and Immunological ConsequencesMeghan J. O'Melia0Amanda W. Lund1Susan N. Thomas2Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive NW, Atlanta, GA 30332, USADepartments of Cell Developmental Cancer Biology, Molecular Microbiology & Immunology, and Dermatology, Knight Cancer Institute, Oregon Health & Science University, 2720 SW Moody Avenue, KR-CDCB, Portland, OR 97239, USA; Corresponding authorWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive NW, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, 315 Ferst Dr NW, Georgia Institute of Technology, Atlanta, GA 30332, USA; George W. Woodruff School of Mechanical Engineering, 801 Ferst Dr NW, Georgia Institute of Technology, Atlanta, GA 30332, USA; Winship Cancer Institute, 1365 Clifton Rd, Emory University, Atlanta, GA 30322, USA; Corresponding authorLymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph node biomechanics in immunity. We present experimental tools that enable quantitative analysis of lymphatic transport and lymph node dynamics in vitro and in vivo. Finally, we discuss the current understanding for how changes in lymphatic transport and lymph node biomechanics contribute to pathogenesis of conditions including cancer, aging, neurodegeneration, and infection. : Lymphology; Biophysics; Biomechanics; Biological Sciences Tools Subject Areas: Lymphology, Biophysics, Biomechanics, Biological Sciences Toolshttp://www.sciencedirect.com/science/article/pii/S2589004219304559
collection DOAJ
language English
format Article
sources DOAJ
author Meghan J. O'Melia
Amanda W. Lund
Susan N. Thomas
spellingShingle Meghan J. O'Melia
Amanda W. Lund
Susan N. Thomas
The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences
iScience
author_facet Meghan J. O'Melia
Amanda W. Lund
Susan N. Thomas
author_sort Meghan J. O'Melia
title The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences
title_short The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences
title_full The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences
title_fullStr The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences
title_full_unstemmed The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences
title_sort biophysics of lymphatic transport: engineering tools and immunological consequences
publisher Elsevier
series iScience
issn 2589-0042
publishDate 2019-12-01
description Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph node biomechanics in immunity. We present experimental tools that enable quantitative analysis of lymphatic transport and lymph node dynamics in vitro and in vivo. Finally, we discuss the current understanding for how changes in lymphatic transport and lymph node biomechanics contribute to pathogenesis of conditions including cancer, aging, neurodegeneration, and infection. : Lymphology; Biophysics; Biomechanics; Biological Sciences Tools Subject Areas: Lymphology, Biophysics, Biomechanics, Biological Sciences Tools
url http://www.sciencedirect.com/science/article/pii/S2589004219304559
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