Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin

Titin is considered an integrator of muscle cell proteins but direct evidence is limited. Here, titin is inactivated in adult mouse muscles, which causes sarcomere disassembly, protein mis-expression and force impairment, recapitulating key alterations in critical illness myopathy patient muscles.

Bibliographic Details
Main Authors:	Sandra Swist, Andreas Unger, Yong Li, Anja Vöge, Marion von Frieling-Salewsky, Åsa Skärlén, Nicola Cacciani, Thomas Braun, Lars Larsson, Wolfgang A. Linke
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18131-2

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spelling	doaj-302edbcae576463d8910dcb3be630c602021-09-12T11:47:26ZengNature Publishing GroupNature Communications2041-17232020-09-0111111810.1038/s41467-020-18131-2Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titinSandra Swist0Andreas Unger1Yong Li2Anja Vöge3Marion von Frieling-Salewsky4Åsa Skärlén5Nicola Cacciani6Thomas Braun7Lars Larsson8Wolfgang A. Linke9Department of Systems Physiology, Ruhr University BochumInstitute of Physiology II, University of MunsterInstitute of Physiology II, University of MunsterDepartment of Systems Physiology, Ruhr University BochumInstitute of Physiology II, University of MunsterDepartment of Clinical Neuroscience, Clinical Neurophysiology, Karolinska InstituteDepartment of Physiology and Pharmacology, Karolinska InstituteDepartment of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung ResearchDepartment of Physiology and Pharmacology, Karolinska InstituteInstitute of Physiology II, University of MunsterTitin is considered an integrator of muscle cell proteins but direct evidence is limited. Here, titin is inactivated in adult mouse muscles, which causes sarcomere disassembly, protein mis-expression and force impairment, recapitulating key alterations in critical illness myopathy patient muscles.https://doi.org/10.1038/s41467-020-18131-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sandra Swist Andreas Unger Yong Li Anja Vöge Marion von Frieling-Salewsky Åsa Skärlén Nicola Cacciani Thomas Braun Lars Larsson Wolfgang A. Linke
spellingShingle	Sandra Swist Andreas Unger Yong Li Anja Vöge Marion von Frieling-Salewsky Åsa Skärlén Nicola Cacciani Thomas Braun Lars Larsson Wolfgang A. Linke Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin Nature Communications
author_facet	Sandra Swist Andreas Unger Yong Li Anja Vöge Marion von Frieling-Salewsky Åsa Skärlén Nicola Cacciani Thomas Braun Lars Larsson Wolfgang A. Linke
author_sort	Sandra Swist
title	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_short	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_full	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_fullStr	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_full_unstemmed	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_sort	maintenance of sarcomeric integrity in adult muscle cells crucially depends on z-disc anchored titin
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Titin is considered an integrator of muscle cell proteins but direct evidence is limited. Here, titin is inactivated in adult mouse muscles, which causes sarcomere disassembly, protein mis-expression and force impairment, recapitulating key alterations in critical illness myopathy patient muscles.
url	https://doi.org/10.1038/s41467-020-18131-2
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Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin

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