Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies

Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies

Immunological events in acute HIV-1 infection before peak viremia (hyperacute phase) may contribute to the development of broadly cross-neutralizing antibodies. Here, we used pre-infection and acute-infection peripheral blood mononuclear cells and plasma samples from 22 women, including 10 who initi...

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Bibliographic Details
Main Authors: Jenniffer M. Mabuka, Anne-Sophie Dugast, Daniel M. Muema, Tarylee Reddy, Yathisha Ramlakhan, Zelda Euler, Nasreen Ismail, Amber Moodley, Krista L. Dong, Lynn Morris, Bruce D. Walker, Galit Alter, Thumbi Ndung’u
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
B-cell subsets
acute HIV
CXCL13
cross-neutralizing antibodies
BAFF
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01104/full

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