The Co-inhibitor BTLA Is Functional in ANCA-Associated Vasculitis and Suppresses Th17 Cells

The Co-inhibitor BTLA Is Functional in ANCA-Associated Vasculitis and Suppresses Th17 Cells

Objectives: The activation and inhibition of T-cells has been well-studied under physiological conditions. Co-inhibition is an important mechanism to keep effector T-cells in check. Co-inhibitors mediate peripheral self-tolerance and limit the immune response. Dysfunctional co-inhibition is associat...

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Bibliographic Details
Main Authors: Kai Werner, Sebastian Dolff, Yang Dai, Xin Ma, Alexandra Brinkhoff, Johannes Korth, Anja Gäckler, Hana Rohn, Ming Sun, Jan Willem Cohen Tervaert, Pieter van Paassen, Andreas Kribben, Oliver Witzke, Benjamin Wilde
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
ANCA vasculitis
BTLA
co-inhibition
immune checkpoint
Th17 cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02843/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02843/full

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