Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin<sup>&#174;</sup>), the monoclonal antibody that recogn...

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Bibliographic Details
Main Authors: Weronika Gawęda, Magdalena Osial, Michał Żuk, Marek Pękała, Aleksander Bilewicz, Pawel Krysinski
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Nanomaterials
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Online Access:https://www.mdpi.com/2079-4991/10/2/288
Description
Summary:Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin<sup>&#174;</sup>), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho<sup>3+</sup>-doped bioconjugates were carried out as a preliminary step for future replacement of &#8216;cold&#8217; Ho with <sup>166</sup>Ho radionuclide, emitting &#8216;soft&#8217; beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both: active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers.
ISSN:2079-4991