Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

Nramp family transporters—expressed in organisms from bacteria to humans—enable uptake of essential divalent transition metals via an alternating-access mechanism that also involves proton transport. We present high-resolution structures of Deinococcus radiodurans (Dra)Nramp in multiple conformation...

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Bibliographic Details
Main Authors: Aaron T Bozzi, Christina M Zimanyi, John M Nicoludis, Brandon K Lee, Casey H Zhang, Rachelle Gaudet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
secondary transporter
LeuT fold
MntH
Deinococcus radiodurans
x-ray crystallography
SLC11
Online Access:https://elifesciences.org/articles/41124

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