Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates
Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions. To form the salts, neutralization with calcium carbonate followed by cation exchange by means of magnesium or zinc sulfates was...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2015-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391400032F.pdf |
| Summary: | Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were
synthesized by sulfonation of hydroquinone with sulfuric acid under mild
conditions. To form the salts, neutralization with calcium carbonate followed
by cation exchange by means of magnesium or zinc sulfates was performed. The
dobesilates were characterized by standard spectral methods and by AAS for
metal content and then tested for inhibitory activity against aminopeptidase
N. Calcium and magnesium 2,5-dihydroxybenzene sulfonates exhibited rather
weak inhibitory activity to aminopeptidase N as demonstrated by IC50 values
of 978.0 and 832.1 mmol l-1 respectively while zinc 2,5-dihydroxybenzene
sulfonate reached the more significant inhibitory activity characterized by
IC50 77.4 mmol l-1. The inhibitory activity results suggest that the
inhibition of aminopeptidase N could play a role in the anti-angiogenic
activity of 2,5-dihydroxybenzenesulfonates. |
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| ISSN: | 0352-5139 1820-7421 |