Molecular detection of human papillomavirus-16 among Sudanese patients diagnosed with squamous cell carcinoma and salivary gland carcinoma

• Main Authors: Fatima E. Mohamed, Leena N. Aldayem, Maisa A. Hemaida, Omayma Siddig, Zeinab H. Osman, Irene R. Shafig, Mohamed A. M. Salih, Mohamed S. Muneer, Rowa Hassan, Eiman Siddig Ahmed, Lamis Ahmed Hassan, Osama El Hadi Bakheet, Ali M. M. Edris, Ayman Ahmed, Nouh S. Mohamed, Emmanuel E. Siddig
• Format: Article
• Language: English
• Published: BMC 2021-02-01
• Series: BMC Research Notes
• Subjects: Human papilloma virus; Squamous cell carcinomas; Sudan
• Online Access: https://doi.org/10.1186/s13104-021-05471-5

Abstract Objective Human papillomavirus (HPV) gained momentum as a potential etiological factor for many types of cancers. Therefore, the aim of this study was to assess the prevalence of HPV-16 infection among Sudanese patients diagnosed with Squamous Cell Carcinoma (SCC) and Salivary Gland Carcinoma. A descriptive, hospital-based study was conducted. 150 formalin-fixed paraffin-embedded blocks were collected. Results The study population included a total of 150 patients aged between 18 to 87 years with a mean age of 48.8 ± 11.9 years. Based on gender, females constituted 46.7% while males constituted 53.3%. The 150 patients were classified into 40 (26.0%) esophageal, 30 (20.0%) nasopharyngeal, 18 (12.0%) conjunctival, 18 (12.0%) tongue 12 (8.0%) laryngeal, 8 (5.3%) lip, 6 (4.0%) oropharyngeal, 6 (4.0%) mucoepidermoid, and 6 (4.0%) adenoid cystic, and 6 (4.0%) myoepithelial carcinomas. Odds ratio for male and female diagnosed with carcinoma was 1.025 [0.439–2.394, 95% CI]. Molecular detection of HPV-16 revealed a prevalence of 26 (17.3%) patients were positive for HPV-16. According to cancer diagnosis, esophageal SCC patients showed a high proportion of HPV-16; 14/40 (35.0%). A statistically significant difference was seen for the distribution of HPV-16 positive patients based on cancer diagnosis, P value 0.001.