Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk

Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk

Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this study to statistically and functionally characterize a gene-gene intera...

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Bibliographic Details
Main Authors: Taehyeung Kim, Sang-Cheol Bae, Changwon Kang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Arthritis Research & Therapy
Subjects:
Autoimmune disease
Cytokine
Epistasis
Gene-gene interaction
Gene polymorphism
Inflammatory disease
Online Access:http://link.springer.com/article/10.1186/s13075-020-02181-4

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