A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Dietary vitamin A/all-<i>trans</i> retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is, however, not expressed in...

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Bibliographic Details
Main Authors: Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
retinol binding protein 4 receptor 2
RBP4
Rbpr2
STRA6
all-<i>trans</i> retinol transport
photoreceptor cell
Online Access:https://www.mdpi.com/2073-4409/9/5/1099

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