Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term surv...

Full description

Bibliographic Details
Main Authors: Adam Nowakowski, Piotr Walczak, Barbara Lukomska, Miroslaw Janowski
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2016/4956063
id doaj-2fac647191414689b570c3ce00433bd9
record_format Article
spelling doaj-2fac647191414689b570c3ce00433bd92020-11-24T22:48:53ZengHindawi LimitedStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/49560634956063Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and SurvivalAdam Nowakowski0Piotr Walczak1Barbara Lukomska2Miroslaw Janowski3NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, PolandRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, 733 N. Broadway Street, Room 649, Baltimore, MD 21205, USANeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, PolandNeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, PolandMesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies.http://dx.doi.org/10.1155/2016/4956063
collection DOAJ
language English
format Article
sources DOAJ
author Adam Nowakowski
Piotr Walczak
Barbara Lukomska
Miroslaw Janowski
spellingShingle Adam Nowakowski
Piotr Walczak
Barbara Lukomska
Miroslaw Janowski
Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
Stem Cells International
author_facet Adam Nowakowski
Piotr Walczak
Barbara Lukomska
Miroslaw Janowski
author_sort Adam Nowakowski
title Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
title_short Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
title_full Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
title_fullStr Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
title_full_unstemmed Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
title_sort genetic engineering of mesenchymal stem cells to induce their migration and survival
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2016-01-01
description Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their relatively easy derivation and broad range of differentiation capabilities, either naturally or induced through cell engineering. However, efficient methods of delivery to diseased tissues and the long-term survival of grafted cells still need improvement. Here, we review genetic engineering approaches designed to enhance the migratory capacities of MSCs, as well as extend their survival after transplantation by the modulation of prosurvival approaches, including prevention of senescence and apoptosis. We highlight some of the latest examples that explore these pivotal points, which have great relevance in cell-based therapies.
url http://dx.doi.org/10.1155/2016/4956063
work_keys_str_mv AT adamnowakowski geneticengineeringofmesenchymalstemcellstoinducetheirmigrationandsurvival
AT piotrwalczak geneticengineeringofmesenchymalstemcellstoinducetheirmigrationandsurvival
AT barbaralukomska geneticengineeringofmesenchymalstemcellstoinducetheirmigrationandsurvival
AT miroslawjanowski geneticengineeringofmesenchymalstemcellstoinducetheirmigrationandsurvival
_version_ 1725678367636717568

Similar Items