Bioreducible PEI-siRNA Nanocomplex for Liver Cancer Therapy: Transfection, Biodistribution, and Tumor Growth Inhibition In Vivo

Bioreducible PEI-siRNA Nanocomplex for Liver Cancer Therapy: Transfection, Biodistribution, and Tumor Growth Inhibition In Vivo

A bioreducible polyethylenimine (SS-PEI) was successfully applied as a nonviral carrier for the delivery of plasmid DNA and VEGF-siRNA in vitro and in vivo. The SS-PEI could strongly condense DNA or siRNA into nanosized complexes (below 200 nm) with positive surface charges. In vitro transfection ex...

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Bibliographic Details
Main Authors:	Wei Xia, Yan Li, Bo Lou, Peijun Wang, Xiaolong Gao, Chao Lin
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	Journal of Nanomaterials
Online Access:	http://dx.doi.org/10.1155/2013/384717

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