Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by <i>MLL-AF4</i> Translocations

Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by <i>MLL-AF4</i> Translocations

<i>Mixed lineage leukemia</i> (<i>MLL</i>) <i>(KMT2A)</i> rearrangements (<i>KMT2A</i>r) play a crucial role in leukemogenesis. Dependent on age, major differences exist regarding disease frequency, main fusion partners and prognosis. In infants, up to...

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Bibliographic Details
Main Authors: Kathy-Ann Secker, Lukas Bruns, Hildegard Keppeler, Johan Jeong, Thomas Hentrich, Julia M. Schulze-Hentrich, Barbara Mankel, Falko Fend, Dominik Schneidawind, Corina Schneidawind
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
<i>KMT2A</i>-rearranged leukemia
CRISPR/Cas9
cell of origin
Online Access:https://www.mdpi.com/2072-6694/12/6/1487

Internet

https://www.mdpi.com/2072-6694/12/6/1487

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