Modulation of the Aβ-Peptide-Aggregation Pathway by Active Compounds From Platycladus orientalis Seed Extract in Alzheimer’s Disease Models

Modulation of the Aβ-Peptide-Aggregation Pathway by Active Compounds From Platycladus orientalis Seed Extract in Alzheimer’s Disease Models

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neuronal loss, cognitive impairment, and aphasia. Aggregation of β-amyloid (Aβ) peptide in the brain is considered a key mechanism in the development of AD. In the past 20 years, many compounds have been developed to inhibit Aβ...

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Bibliographic Details
Main Authors: Li Yan, Xiang He, Yufan Jin, Jiawei Wang, Fengying Liang, Rongrong Pei, Peibo Li, Yonggang Wang, Weiwei Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Aβ-peptide aggregation
Platycladus orientalis seed
cognitive function
isocupressic acid
β-secretase 1
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00207/full

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