| Summary: | The TNF receptor superfamily member 25 (TNFRSF25) is part of the tumor necrosis factor receptor superfamily and contains a typical death domain. It is also known as DR3, TRAMP, LARD, WSL-1, Apo-3 and TR3, and has a vital role in regulating cell proliferation, differentiation and apoptosis. In this study, a homologue of the TNFRSF25 gene was identified in grass carp (Ctenopharyngodon idella). It encodes a transmembrane protein with an extracellular domain containing a cysteine-rich domain and an intracellular domain containing a death domain. It is an orthologue of fish TNFRSF1ALs and shares conserved gene synteny with human TNFRSF25. Expression studies showed that CiTNFRSF25 was constitutively expressed in the majority of fish tissues and can be modulated by interleukin 4/13B and infection by F. columnare. To our knowledge, this is the first report describing the existence of a TNFRSF25 homologue in teleost fish. Keywords: Evolution, Expression, Fish, Grass carp, Infection, Tumor necrosis factor receptor superfamily
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