| Summary: | Penicillin antibiotics are widely used for antibacterial treatment. Quantitative determination of these drugs in bio-fluids is constantly under a great need. HPLC is the more common analytical technique for this purpose. During the last decades, Green Analytical Chemistry is on the rise and is proven a new tendency. Sample preparation, as a crucial step of the analytical procedure, is strongly affected and determined by this new scientific perspective. Therefore, a variety of new microextraction techniques have been developed, which can be combined with the chromatographic determination of biofluids. In this review, current trends and methods of sample preparation are presented, which are appropriate to be used in order to extract penicillin antibiotics from biological samples prior to their HPLC separation. These methods are compatible with the principles of green analytical chemistry, which is an extreme necessity of our era, for both environmental and economic reasons. The evolution and establishment of these microextraction analytical techniques for sample preparation constitute a significant field of modern research due to their importance in the whole analytical procedure. Bioanalytical applications are set in the spotlight.
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