TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor family member with regulatory functions in inflammation and immunity

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor family member with regulatory functions in inflammation and immunity

Interleukin-1R like receptors (ILRs) and Toll Like Receptors (TLRs) are key receptors of innate immunity, inflammation and orientation of the adaptive response. They belong to a superfamily characterized by the presence of a conserved intracellular domain, the Toll/IL-1R (TIR) domain, which is invol...

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Bibliographic Details
Main Authors: Federica eRiva, Eduardo eBonavita, Elisa eBarbati, Marta eMuzio, Alberto eMantovani, Cecilia eGarlanda
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Immunology
Subjects:
Infection
Inflammation
Interleukin-1
cytokine
Toll like receptors
inflammation-associated cancer
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00322/full

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