Depletion of the p43 mitochondrial T3 receptor increases Sertoli cell proliferation in mice.

Depletion of the p43 mitochondrial T3 receptor increases Sertoli cell proliferation in mice.

Among T3 receptors, TRα1 is ubiquitous and its deletion or a specific expression of a dominant-negative TRα1 isoform in Sertoli cell leads to an increase in testis weight and sperm production. The identification of a 43-kDa truncated form of the nuclear receptor TRα1 (p43) in the mitochondrial matri...

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Bibliographic Details
Main Authors: Betty Fumel, Stéphanie Roy, Sophie Fouchécourt, Gabriel Livera, Anne-Simone Parent, François Casas, Florian Guillou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3767600?pdf=render

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