miR-21-5p protects IL-1β-induced human chondrocytes from degradation

miR-21-5p protects IL-1β-induced human chondrocytes from degradation

Abstract Objective Osteoarthritis (OA) is a prevalent degenerative disease caused by various factors. MicroRNAs are important regulators in OA. MiR-21-5p expression is decreased in OA cartilage, but the effects of modulating miR-21-5p on cartilage regeneration are unknown. Therefore, our aim was to...

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Bibliographic Details
Main Authors: Hai Zhu, Xin Yan, Meng Zhang, Feng Ji, Shouguo Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoarthritis
Chondrocytes
miR-21-5p
COL2A1
ADAMTS5
MMP13
Online Access:http://link.springer.com/article/10.1186/s13018-019-1160-7

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