Population bias in somatic measurement of microsatellite instability status

Population bias in somatic measurement of microsatellite instability status

Abstract Microsatellite instability (MSI) is a key secondary effect of a defective DNA mismatch repair mechanism resulting in incorrectly replicated microsatellites in many malignant tumors. Historically, MSI detection has been performed by fragment analysis (FA) on a panel of representative genomic...

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Bibliographic Details
Main Authors: Michelle Saul, Kelsey Poorman, Hongseok Tae, Ari Vanderwalde, Phillip Stafford, David Spetzler, Wolfgang M. Korn, Zoran Gatalica, Jeff Swensen
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Cancer Medicine
Subjects:
checkpoint inhibitor
DNA mismatch repair
immunotherapy
microsatellite instability
next‐generation sequencing
population bias
Online Access:https://doi.org/10.1002/cam4.3294

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