Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii

Background: Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine...

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Main Authors: Jalal Mardaneh, Hamid Beyzaei, Seyed Hadi Hashemi, Behzad Ghasemi, Abbas Rahdar
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2020-06-01
Series:Pharmaceutical Sciences
Subjects:
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-33270
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spelling doaj-2f607f29b095475b8ab04c25f8296b392021-04-02T16:32:42ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862020-06-0126218419210.34172/PS.2020.12ps-33270Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumanniiJalal Mardaneh0Hamid Beyzaei1Seyed Hadi Hashemi2Behzad Ghasemi3Abbas Rahdar4Department of Microbiology, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran.Department of Clinical Sciences, Faculty of Veterinary Medicine, Zabol University, Zabol, Iran.Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran.Department of Physics, Faculty of Science, University of Zabol, Zabol, Iran.Background: Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii.Methods: Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240 μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations. Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values.Results: Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations. Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024 µg ml-1) and MBCs (128-2048 µg ml-1).Conclusion: Among synthetic chemicals and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathologic effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.https://ps.tbzmed.ac.ir/PDF/ps-33270antibacterial effectacinetobacter baumanniicu/fe3o4@sio2 nanocompositescurcuma longagreen tea catechinstrachyspermum ammi
collection DOAJ
language English
format Article
sources DOAJ
author Jalal Mardaneh
Hamid Beyzaei
Seyed Hadi Hashemi
Behzad Ghasemi
Abbas Rahdar
spellingShingle Jalal Mardaneh
Hamid Beyzaei
Seyed Hadi Hashemi
Behzad Ghasemi
Abbas Rahdar
Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii
Pharmaceutical Sciences
antibacterial effect
acinetobacter baumannii
cu/fe3o4@sio2 nanocomposites
curcuma longa
green tea catechins
trachyspermum ammi
author_facet Jalal Mardaneh
Hamid Beyzaei
Seyed Hadi Hashemi
Behzad Ghasemi
Abbas Rahdar
author_sort Jalal Mardaneh
title Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii
title_short Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii
title_full Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii
title_fullStr Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii
title_full_unstemmed Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii
title_sort comparative evaluation of the inhibitory potential of synthetic n-heterocycles, cu/fe3o4@sio2 nanocomposites and some natural products against non-resistant and antibiotic-resistant acinetobacter baumannii
publisher Tabriz University of Medical Sciences
series Pharmaceutical Sciences
issn 2383-2886
publishDate 2020-06-01
description Background: Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii.Methods: Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240 μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations. Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values.Results: Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations. Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024 µg ml-1) and MBCs (128-2048 µg ml-1).Conclusion: Among synthetic chemicals and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathologic effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.
topic antibacterial effect
acinetobacter baumannii
cu/fe3o4@sio2 nanocomposites
curcuma longa
green tea catechins
trachyspermum ammi
url https://ps.tbzmed.ac.ir/PDF/ps-33270
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