The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gels

<p>Bacteriophages (phages) are natural particles to deal with bacteria. The resistance of bacteria to various antibiotics has accelerated in recent years and phages can be used for each particular strain. The best way to deal with superficial infections is topical application of the drug. One...

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Main Authors: Meysam Adibi, Ava Soltani Hekmat, Nazanin Mobasher, Younes Ghasemi, Milad Mohkam, Shima Jafari, Mohammad Ali Mobasher
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2017-03-01
Series:Trends in Pharmaceutical Sciences
Online Access:http://tips.sums.ac.ir/index.php/TiPS/article/view/112
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spelling doaj-2f6057fa2c3e4f1cbe37fea61fcc4d7e2020-11-25T01:11:22ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-37222423-56522017-03-0131192410.1111/tips.v3i1.11274The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gelsMeysam AdibiAva Soltani HekmatNazanin MobasherYounes GhasemiMilad MohkamShima JafariMohammad Ali Mobasher<p>Bacteriophages (phages) are natural particles to deal with bacteria. The resistance of bacteria to various antibiotics has accelerated in recent years and phages can be used for each particular strain. The best way to deal with superficial infections is topical application of the drug. One of the best way is the use of water-based gels such as hydroxy propyl methyl cellulose (HPMC). In addition to sustain drug release properties of the gel base, HPMC itself has healing properties. The final composition of the gel should has property lasting right time on the woundwhile release a number of the appropriate phages per unit of time. After Isolation and purification of phage, it has been trapped into HPMC gel. Gels with different concentrationsused to create plaques and show the release rate of the phage gel. Finally, it was shown that the 2% HPMC has most appropriate pharmaceutical features In terms of the release and durability on the site of infection.</p>http://tips.sums.ac.ir/index.php/TiPS/article/view/112
collection DOAJ
language English
format Article
sources DOAJ
author Meysam Adibi
Ava Soltani Hekmat
Nazanin Mobasher
Younes Ghasemi
Milad Mohkam
Shima Jafari
Mohammad Ali Mobasher
spellingShingle Meysam Adibi
Ava Soltani Hekmat
Nazanin Mobasher
Younes Ghasemi
Milad Mohkam
Shima Jafari
Mohammad Ali Mobasher
The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gels
Trends in Pharmaceutical Sciences
author_facet Meysam Adibi
Ava Soltani Hekmat
Nazanin Mobasher
Younes Ghasemi
Milad Mohkam
Shima Jafari
Mohammad Ali Mobasher
author_sort Meysam Adibi
title The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gels
title_short The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gels
title_full The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gels
title_fullStr The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gels
title_full_unstemmed The effects of HPMC concentration as an efficient pharmaceutical dosage form on phage release pattern from gels
title_sort effects of hpmc concentration as an efficient pharmaceutical dosage form on phage release pattern from gels
publisher Shiraz University of Medical Sciences
series Trends in Pharmaceutical Sciences
issn 2423-3722
2423-5652
publishDate 2017-03-01
description <p>Bacteriophages (phages) are natural particles to deal with bacteria. The resistance of bacteria to various antibiotics has accelerated in recent years and phages can be used for each particular strain. The best way to deal with superficial infections is topical application of the drug. One of the best way is the use of water-based gels such as hydroxy propyl methyl cellulose (HPMC). In addition to sustain drug release properties of the gel base, HPMC itself has healing properties. The final composition of the gel should has property lasting right time on the woundwhile release a number of the appropriate phages per unit of time. After Isolation and purification of phage, it has been trapped into HPMC gel. Gels with different concentrationsused to create plaques and show the release rate of the phage gel. Finally, it was shown that the 2% HPMC has most appropriate pharmaceutical features In terms of the release and durability on the site of infection.</p>
url http://tips.sums.ac.ir/index.php/TiPS/article/view/112
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