Effect of Extracts of Cloves (Syzygium Aromaticum) on Hepatic Cell Damage and Oxidative Stress Caused by Diabetes in Adult Rats

• Main Authors: Tala Pourlak, Monireh Halimi, Tannaz Pourlak, Parham Maroufi, Saber Ghaderpour, Arefeh Shokoohi
• Format: Article
• Language: English
• Published: Gonabad University of Medical Sciences (GMU) 2020-09-01
• Series: Ufuq-i Dānish
• Subjects: cloves; oxidative stress; diabetes; insulin
• Online Access: http://hms.gmu.ac.ir/article-1-3534-en.html
• ISSN: 1735-1855; 2252-0805

Aims: In this study, we investigated the effect of clove extract (Syzygium aromaticum) on liver cell damage and oxidative stress caused by diabetes in adult rats. Methods & Materials: For this study, 28 female rats were collected and divided into four groups: A: Control group; B: Diabetic Control group (DC) which received 20% glycerol dissolved in normal saline as carriers; C: Diabetic rats (DSA) treated with cloves hydroalcoholic extract (4 mg/kg); d) diabetic rats (DG) treated with glibenclamide (5 mg/kg) as a standard drug. Findings: The fasting blood sugar and serum triglyceride levels in the DC group increased significantly compared to the control group (P<0.05). In DC, DG, and DSA groups, high-density lipoprotein, and serum insulin levels decreased significantly compared to the control group (P<0.05). Also, in DG and DSA groups, high-density lipoprotein and serum insulin levels increased significantly compared to the DC group. Conclusion: Cloves can affect fasting blood sugar, serum insulin levels, serum fat profile levels, and prevent liver tissue damage in diabetic rats caused by streptozotocin.