Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
High protein diets are known to improve metabolic parameters including adiposity and glucose homeostasis. Here the authors demonstrate that preabsorptive upper small intestinal protein-sensing mechanisms mediated by peptide transporter 1 improve glucose homeostasis by inhibiting hepatic glucose prod...
Main Authors: | Helen J. Dranse, T. M. Zaved Waise, Sophie C. Hamr, Paige V. Bauer, Mona A. Abraham, Brittany A. Rasmussen, Tony K. T. Lam |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03490-8 |
Similar Items
-
Regulation profile of the intestinal peptide transporter 1 (PepT1)
by: Wang CY, et al.
Published: (2017-12-01) -
Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
by: T. M. Zaved Waise, et al.
Published: (2019-02-01) -
Peptide transporter 1 (PepT1) in fish: A review
by: Junli Wang, et al.
Published: (2017-09-01) -
Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine ModelSummary
by: Emilie Viennois, et al.
Published: (2016-05-01) -
Butyrate transcriptionally enhances peptide transporter PepT1 expression and activity.
by: Guillaume Dalmasso, et al.
Published: (2008-06-01)