Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing

High protein diets are known to improve metabolic parameters including adiposity and glucose homeostasis. Here the authors demonstrate that preabsorptive upper small intestinal protein-sensing mechanisms mediated by peptide transporter 1 improve glucose homeostasis by inhibiting hepatic glucose prod...

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Bibliographic Details
Main Authors: Helen J. Dranse, T. M. Zaved Waise, Sophie C. Hamr, Paige V. Bauer, Mona A. Abraham, Brittany A. Rasmussen, Tony K. T. Lam
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03490-8

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