LARP7 family proteins have conserved function in telomerase assembly

LARP7 family proteins have conserved function in telomerase assembly

The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.

Bibliographic Details
Main Authors: Laura C. Collopy, Tracy L. Ware, Tomas Goncalves, Sunnvør í Kongsstovu, Qian Yang, Hanna Amelina, Corinne Pinder, Ala Alenazi, Vera Moiseeva, Siân R. Pearson, Christine A. Armstrong, Kazunori Tomita
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02296-4
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spelling doaj-2f530556f00745c9b6030e3daa173ab62021-05-11T09:56:41ZengNature Publishing GroupNature Communications2041-17232018-02-01911810.1038/s41467-017-02296-4LARP7 family proteins have conserved function in telomerase assemblyLaura C. Collopy0Tracy L. Ware1Tomas Goncalves2Sunnvør í Kongsstovu3Qian Yang4Hanna Amelina5Corinne Pinder6Ala Alenazi7Vera Moiseeva8Siân R. Pearson9Christine A. Armstrong10Kazunori Tomita11Chromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonChromosome Maintenance Group, UCL Cancer Institute, University College LondonThe telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.https://doi.org/10.1038/s41467-017-02296-4
collection DOAJ
language English
format Article
sources DOAJ
author Laura C. Collopy
Tracy L. Ware
Tomas Goncalves
Sunnvør í Kongsstovu
Qian Yang
Hanna Amelina
Corinne Pinder
Ala Alenazi
Vera Moiseeva
Siân R. Pearson
Christine A. Armstrong
Kazunori Tomita
spellingShingle Laura C. Collopy
Tracy L. Ware
Tomas Goncalves
Sunnvør í Kongsstovu
Qian Yang
Hanna Amelina
Corinne Pinder
Ala Alenazi
Vera Moiseeva
Siân R. Pearson
Christine A. Armstrong
Kazunori Tomita
LARP7 family proteins have conserved function in telomerase assembly
Nature Communications
author_facet Laura C. Collopy
Tracy L. Ware
Tomas Goncalves
Sunnvør í Kongsstovu
Qian Yang
Hanna Amelina
Corinne Pinder
Ala Alenazi
Vera Moiseeva
Siân R. Pearson
Christine A. Armstrong
Kazunori Tomita
author_sort Laura C. Collopy
title LARP7 family proteins have conserved function in telomerase assembly
title_short LARP7 family proteins have conserved function in telomerase assembly
title_full LARP7 family proteins have conserved function in telomerase assembly
title_fullStr LARP7 family proteins have conserved function in telomerase assembly
title_full_unstemmed LARP7 family proteins have conserved function in telomerase assembly
title_sort larp7 family proteins have conserved function in telomerase assembly
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.
url https://doi.org/10.1038/s41467-017-02296-4
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AT tomasgoncalves larp7familyproteinshaveconservedfunctionintelomeraseassembly
AT sunnvørikongsstovu larp7familyproteinshaveconservedfunctionintelomeraseassembly
AT qianyang larp7familyproteinshaveconservedfunctionintelomeraseassembly
AT hannaamelina larp7familyproteinshaveconservedfunctionintelomeraseassembly
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