Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease
Editorial summary Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pat...
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2017-07-01
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| Series: | Genome Medicine |
| Online Access: | http://link.springer.com/article/10.1186/s13073-017-0459-4 |
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doaj-2f4fed883b534540b58b0d19949140812020-11-24T21:24:57ZengBMCGenome Medicine1756-994X2017-07-01911310.1186/s13073-017-0459-4Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel diseaseHiutung Chu0California Institute of TechnologyEditorial summary Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen clearance, and failure to sense beneficial commensal microbes. These findings highlight the importance of maintaining bi-directional communication at the mucosal interface during intestinal homeostasis.http://link.springer.com/article/10.1186/s13073-017-0459-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hiutung Chu |
| spellingShingle |
Hiutung Chu Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease Genome Medicine |
| author_facet |
Hiutung Chu |
| author_sort |
Hiutung Chu |
| title |
Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_short |
Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_full |
Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_fullStr |
Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_full_unstemmed |
Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_sort |
host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| publisher |
BMC |
| series |
Genome Medicine |
| issn |
1756-994X |
| publishDate |
2017-07-01 |
| description |
Editorial summary Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen clearance, and failure to sense beneficial commensal microbes. These findings highlight the importance of maintaining bi-directional communication at the mucosal interface during intestinal homeostasis. |
| url |
http://link.springer.com/article/10.1186/s13073-017-0459-4 |
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AT hiutungchu hostgenemicrobiomeinteractionsmolecularmechanismsininflammatoryboweldisease |
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