Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one
The reaction of 3,5-dichloro-4<i>H</i>-1,2,6-thiadiazin-4-one with (<i>R</i>) and (<i>S</i>)-1,3-dimethylpiperazine (1 equiv), in THF, at ca. 20 °C gives (<i>R</i>) and (<i>S</i>)-3-chloro-5-(2,4-dimethylpiperazin-1-yl)-4<i>H</i>...
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MDPI AG
2020-06-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2020/2/M1139 |
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doaj-2f451a6030b74c13ae66d4928476fe072020-11-25T03:18:09ZengMDPI AGMolbank1422-85992020-06-012020M1139M113910.3390/M1139Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-oneAndreas S. Kalogirou0Christopher R. M. Asquith1Panayiotis A. Koutentis2Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P. O. Box 22006, 1516 Nicosia, CyprusDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, CyprusThe reaction of 3,5-dichloro-4<i>H</i>-1,2,6-thiadiazin-4-one with (<i>R</i>) and (<i>S</i>)-1,3-dimethylpiperazine (1 equiv), in THF, at ca. 20 °C gives (<i>R</i>) and (<i>S</i>)-3-chloro-5-(2,4-dimethylpiperazin-1-yl)-4<i>H</i>-1,2,6-thiadiazin-4-ones in 70% and 68% yields, respectively. The new compounds were fully characterized.https://www.mdpi.com/1422-8599/2020/2/M1139substitutionheterocyclethiadiazinepiperazinechirality |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Andreas S. Kalogirou Christopher R. M. Asquith Panayiotis A. Koutentis |
| spellingShingle |
Andreas S. Kalogirou Christopher R. M. Asquith Panayiotis A. Koutentis Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one Molbank substitution heterocycle thiadiazine piperazine chirality |
| author_facet |
Andreas S. Kalogirou Christopher R. M. Asquith Panayiotis A. Koutentis |
| author_sort |
Andreas S. Kalogirou |
| title |
Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one |
| title_short |
Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one |
| title_full |
Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one |
| title_fullStr |
Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one |
| title_full_unstemmed |
Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one |
| title_sort |
synthesis of (<em>r</em>) and (<em>s</em>)-3-chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>h</em>-1,2,6-thiadiazin-4-one |
| publisher |
MDPI AG |
| series |
Molbank |
| issn |
1422-8599 |
| publishDate |
2020-06-01 |
| description |
The reaction of 3,5-dichloro-4<i>H</i>-1,2,6-thiadiazin-4-one with (<i>R</i>) and (<i>S</i>)-1,3-dimethylpiperazine (1 equiv), in THF, at ca. 20 °C gives (<i>R</i>) and (<i>S</i>)-3-chloro-5-(2,4-dimethylpiperazin-1-yl)-4<i>H</i>-1,2,6-thiadiazin-4-ones in 70% and 68% yields, respectively. The new compounds were fully characterized. |
| topic |
substitution heterocycle thiadiazine piperazine chirality |
| url |
https://www.mdpi.com/1422-8599/2020/2/M1139 |
| work_keys_str_mv |
AT andreasskalogirou synthesisofemremandemsem3chloro524dimethylpiperazin1yl4emhem126thiadiazin4one AT christopherrmasquith synthesisofemremandemsem3chloro524dimethylpiperazin1yl4emhem126thiadiazin4one AT panayiotisakoutentis synthesisofemremandemsem3chloro524dimethylpiperazin1yl4emhem126thiadiazin4one |
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1724628534783115264 |