Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules

Abstract A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the t...

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Main Authors:	Bhaskar Kummari, Perla Ramesh, Naveen Polkam, Shankaraiah Malthum, M. V. P. S. Vishnuvardhan, Jaya Shree Anireddy
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2018-01-01
Series:	SynOpen
Subjects:	synthesis etodolac oxadiozoles triazoles cytotoxicity
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591754

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spelling	doaj-2f3fad34962942ce8bd8ce47c8c1df822020-11-25T03:14:45ZengGeorg Thieme Verlag KGSynOpen2509-93962018-01-0102010017002410.1055/s-0036-1591754Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole MoleculesBhaskar Kummari0Perla Ramesh1Naveen Polkam2Shankaraiah Malthum3M. V. P. S. Vishnuvardhan4Jaya Shree Anireddy5Centre for Chemical Sciences and Technology Institute of Science and TechnologyNatural Products Chemistry DivisionCentre for Chemical Sciences and Technology Institute of Science and TechnologyCentre for Chemical Sciences and Technology Institute of Science and TechnologyMedicinal chemistry and biotechnology, Indian Institute of Chemical TechnologyCentre for Chemical Sciences and Technology Institute of Science and TechnologyAbstract A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the tested compounds 7c, 7l, and 7n exhibited highest cytotoxic activity against MCF-7 (breast), A549 (lung), and DU-145 (prostate) human cancer cell lines.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591754synthesisetodolacoxadiozolestriazolescytotoxicity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bhaskar Kummari Perla Ramesh Naveen Polkam Shankaraiah Malthum M. V. P. S. Vishnuvardhan Jaya Shree Anireddy
spellingShingle	Bhaskar Kummari Perla Ramesh Naveen Polkam Shankaraiah Malthum M. V. P. S. Vishnuvardhan Jaya Shree Anireddy Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules SynOpen synthesis etodolac oxadiozoles triazoles cytotoxicity
author_facet	Bhaskar Kummari Perla Ramesh Naveen Polkam Shankaraiah Malthum M. V. P. S. Vishnuvardhan Jaya Shree Anireddy
author_sort	Bhaskar Kummari
title	Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules
title_short	Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules
title_full	Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules
title_fullStr	Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules
title_full_unstemmed	Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules
title_sort	design, synthesis, and cytotoxic evaluation of etodolac-1,3,4-oxadiazole-1,2,3-triazole molecules
publisher	Georg Thieme Verlag KG
series	SynOpen
issn	2509-9396
publishDate	2018-01-01
description	Abstract A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the tested compounds 7c, 7l, and 7n exhibited highest cytotoxic activity against MCF-7 (breast), A549 (lung), and DU-145 (prostate) human cancer cell lines.
topic	synthesis etodolac oxadiozoles triazoles cytotoxicity
url	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591754
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Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules

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