Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules

Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules

Abstract A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the t...

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Bibliographic Details
Main Authors: Bhaskar Kummari, Perla Ramesh, Naveen Polkam, Shankaraiah Malthum, M. V. P. S. Vishnuvardhan, Jaya Shree Anireddy
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2018-01-01
Series:SynOpen
Subjects:
synthesis
etodolac
oxadiozoles
triazoles
cytotoxicity
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591754
Description
Summary:Abstract A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the tested compounds 7c, 7l, and 7n exhibited highest cytotoxic activity against MCF-7 (breast), A549 (lung), and DU-145 (prostate) human cancer cell lines.
ISSN:2509-9396

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