MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone

MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone

Multiple sclerosis (MS) is a progressive autoimmune disease characterized by T-cell mediated demyelination in central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a widely used in vivo disease model of MS. Glucocorticoids such as dexamethasone (dex) function as immunosupp...

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Bibliographic Details
Main Authors: Jinhan Nam, Tapani K. Koppinen, Merja H. Voutilainen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
MS
EAE
MANF
dexamethasone
neuroinflammation
UPR
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.640084/full

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