Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice

Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice

Shank2 is an excitatory postsynaptic scaffolding protein strongly implicated in autism spectrum disorders (ASDs). Shank2-mutant mice with a homozygous deletion of exons 6 and 7 (Shank2-KO mice) show decreased NMDA receptor (NMDAR) function and autistic-like behaviors at juvenile [∼postnatal day (P21...

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Bibliographic Details
Main Authors: Ye-Eun Yoo, Seungjoon Lee, Woohyun Kim, Hyosang Kim, Changuk Chung, Seungmin Ha, Jinsu Park, Yeonseung Chung, Hyojin Kang, Eunjoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorders
Shank2
NMDA receptor
memantine
RNA-Seq
synapse
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.712576/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.712576/full

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