Effectiveness of Trino-IB on rat infected with respiratory syncytial virus
The respiratory syncytial virus (RSV) is a common cause of respiratory tract infection. The illness typically begins with a low-grade fever, runny nose, cough and sometimes wheezing. Usage of immunostimulators to prevent infections such as RSV is of great importance. Immunostimulators such Trino-IB...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
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| Series: | Journal of Applied Animal Research |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09712119.2017.1307755 |
| Summary: | The respiratory syncytial virus (RSV) is a common cause of respiratory tract infection. The illness typically begins with a low-grade fever, runny nose, cough and sometimes wheezing. Usage of immunostimulators to prevent infections such as RSV is of great importance. Immunostimulators such Trino-IB are drugs which stimulate immune system by inducing activation or increasing activity of any of its components. Thirty specific pathogen-free Wister rats were put into three groups (10 each). Group A was treated with Trino-IB before and after inoculation with RSV, Group B was inoculated with only RSV and Group C (control) was not given any treatment. Clinical signs, anal temperature were observed daily and rats were sacrificed at day 2, 4, 6, 8 and 10 for histological analysis. Rats in Group B showed more and severe clinical signs of RSV infection alongside histopathological changes of the lungs than the rats in Group A. The results of from the study showed that Trino-IB has effect on the immune system of the rats by suppressing the effect of RSV. The effect of Trino-IB on the infected rat explains the ability of the drug to act as an immune booster as well as to suppress the clinical effect of the virus. |
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| ISSN: | 0971-2119 0974-1844 |