Determination of serum adiponectin relationship with insulin resistance in type 2 diabetics
Background and Aim: Obesity is associated with some chronic morbidity including atherosclerosis, hypertension, and type 2 diabetes which are major components of metabolic syndrome. In the present study, association between insulin resistance and adiponectin, as an anti-inflammatory cytokine, in type...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Birjand University of Medical Sciences and Health Services
2014-02-01
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| Series: | Journal of Birjand University of Medical Sciences |
| Subjects: | |
| Online Access: | http://journal.bums.ac.ir/browse.php?a_code=A-10-113-4&slc_lang=en&sid=1 |
| Summary: | Background and Aim: Obesity is associated with some chronic morbidity including atherosclerosis, hypertension, and type 2 diabetes which are major components of metabolic syndrome.
In the present study, association between insulin resistance and adiponectin, as an anti-inflammatory cytokine, in type 2 obese male diabetics was assessed.
Materials and Methods: In this descriptive study, fasting serum adiponectin, insulin, glucose and insulin resistance were measured in 42 obese male type 2 diabetics (aged 37 - 53 years, weight 80-100kg, 30≤BMI≤36). Pearson’s correlation method was used to determine the association between adiponectin levels with insulin resistance, glucose, and insulin in the cases (P≤0.05).
Results: Pearson’s correlation method showed a significant negative association between serum adiponectin andinsulin resistance (P=0.000(. Besides, a significant correlation was observed between adiponectin level and fasting glucose (P=0.005). But, no correlation was found between serum adiponectin and insulin (P=0.196).
Conclusion: The current study demonstrated that serum adiponectin level, as an anti-inflammation and anti-diabetic cytokine, is a predictive factor of insulin resistance in type 2 diabetics. |
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| ISSN: | 1607-2197 2423-6152 |