RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.

RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.

BRCA1 and BRCA2 are the most well-known breast cancer susceptibility genes. Additional genes involved in DNA repair have been identified as predisposing to breast cancer. One such gene, RAD51C, is essential for homologous recombination repair. Several likely pathogenic RAD51C mutations have been ide...

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Bibliographic Details
Main Authors: Jessica Clague, Greg Wilhoite, Aaron Adamson, Adam Bailis, Jeffrey N Weitzel, Susan L Neuhausen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3182241?pdf=render

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