1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by 1H NMR. Antiproliferative activit...

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Bibliographic Details
Main Authors: Ilona Domracheva, Ruslan Muhamadejev, Marina Petrova, Edvards Liepinsh, Anita Gulbe, Irina Shestakova, Gunars Duburs, Pavel Arsenyan
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
Carmofur
Cytotoxicity
DMPC
Drug delivery
5-Fluorouracil
1H NMR
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015000116

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