Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice

Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice

The activin receptor-like kinase 1 (ALK-1) is a type I cell-surface receptor for the transforming growth factor-β (TGF-β) family of proteins. Hypertension is related to TGF-β1, because increased TGF-β1 expression is correlated with an elevation in arterial pressure (AP) and TGF-β expression is upreg...

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Bibliographic Details
Main Authors: María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Format: Article
Language:English
Published: The Company of Biologists 2015-11-01
Series:Disease Models & Mechanisms
Subjects:
Activin receptor-like kinase 1
Animal model of human disease
Angiotensin II
Arterial pressure
Catecholamines
Intracerebroventricular injection
Nitric oxide
Sympathetic nervous system
Online Access:http://dmm.biologists.org/content/8/11/1427

Internet

http://dmm.biologists.org/content/8/11/1427

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