Inhibition of indoleamine 2,3-dioxygenase 1 synergizes with oxaliplatin for efficient colorectal cancer therapy

Inhibition of indoleamine 2,3-dioxygenase 1 synergizes with oxaliplatin for efficient colorectal cancer therapy

We investigated the immunogenic cell death provoked by oxaliplatin (OXA) and the involvement of OXA-induced immunosuppression in colorectal cancer. Immune-proficient or -deficient mice were employed to evaluate the therapeutic effects of OXA. Immunogenic cell death was characterized by cell-surface...

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Bibliographic Details
Main Authors: Xiaofei Miao, Ye Zhang, Zengyao Li, Longchang Huang, Taojian Xin, Renhui Shen, Tong Wang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
oxaliplatin
colorectal cancer
IDO1
immunogenic cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302618

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