The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

Abstract Background Preserving the integrity of the blood-brain barrier (BBB) is beneficial to avoid further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component of the BBB, promote BBB breakdown in subjects with AIS by secreting inflammatory factors. The glucagon-like...

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Bibliographic Details
Main Authors: Yilong Shan, Sha Tan, Yinyao Lin, Siyuan Liao, Bingjun Zhang, Xiaodong Chen, Jihui Wang, Zhezhi Deng, Qin Zeng, Lei Zhang, Yuge Wang, Xueqiang Hu, Wei Qiu, Lisheng Peng, Zhengqi Lu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Astrocyte
Exendin-4
Blood-brain barrier
Oxygen-glucose deprivation
Ischemic stroke
Online Access:https://doi.org/10.1186/s12974-019-1638-6

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