Modeling amyloids in bacteria

Modeling amyloids in bacteria

<p>Abstract</p> <p>An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged mo...

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Main Authors: Villar-Piqué Anna, Ventura Salvador
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Microbial Cell Factories
Online Access:http://www.microbialcellfactories.com/content/11/1/166
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spelling doaj-2edecf3ed7b04c1e9ae55e02b214dbcf2020-11-25T01:59:16ZengBMCMicrobial Cell Factories1475-28592012-12-0111116610.1186/1475-2859-11-166Modeling amyloids in bacteriaVillar-Piqué AnnaVentura Salvador<p>Abstract</p> <p>An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.</p> http://www.microbialcellfactories.com/content/11/1/166
collection DOAJ
language English
format Article
sources DOAJ
author Villar-Piqué Anna
Ventura Salvador
spellingShingle Villar-Piqué Anna
Ventura Salvador
Modeling amyloids in bacteria
Microbial Cell Factories
author_facet Villar-Piqué Anna
Ventura Salvador
author_sort Villar-Piqué Anna
title Modeling amyloids in bacteria
title_short Modeling amyloids in bacteria
title_full Modeling amyloids in bacteria
title_fullStr Modeling amyloids in bacteria
title_full_unstemmed Modeling amyloids in bacteria
title_sort modeling amyloids in bacteria
publisher BMC
series Microbial Cell Factories
issn 1475-2859
publishDate 2012-12-01
description <p>Abstract</p> <p>An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.</p>
url http://www.microbialcellfactories.com/content/11/1/166
work_keys_str_mv AT villarpiqueanna modelingamyloidsinbacteria
AT venturasalvador modelingamyloidsinbacteria
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