Preconcentration and post-column fluorescent derivatization for the environmental water monitoring of an antihelmintic macrocyclic drug used in livestock

• Main Authors: Emiliano Felici, Chien C. Wang, Cristian Casado, Ana Vicario, Víctor Pereyra, María R. Gómez
• Format: Article
• Language: English
• Published: Elsevier 2019-07-01
• Series: Heliyon
• Subjects: Analytical chemistry; Environmental science; Macrocyclic lactone; Environmental pollution; Fluorescent derivatization; Water analysis
• Online Access: http://www.sciencedirect.com/science/article/pii/S2405844019356853

In this paper, a green analytical methodology based on fluorescence derivatization is proposed for the anti-helminthic drug monitoring ivermectin as environmental emergent contaminant. After sample clean-up, ivermectin was converted into a highly fluorescent derivative through a catalytic oxidation process followed by dehydration and tautomerization. Under optimal experimental conditions, a linear response was obtained for ivermectin within the range 0.38–600 μg L−1, with detection and quantification limits of 0.11 and 0.38 μg L−1, both values are lower than other previously reported. This method has been applied for ivermectin determination in environmental water samples at trace levels, showing its potential for contamination monitoring.