Comparative Analysis of Stk11/Lkb1 Versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9

Comparative Analysis of Stk11/Lkb1 Versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9

This study focused on STK11, PTEN, KRAS, and TP53, which are often found to be mutated in lung cancer. We compared Stk11 and Pten implication in lung cancer in combination with loss of Trp53 and gain of function of Kras in a CRISPR/Cas9 mouse model. Mice with loss of Stk11, Trp53, and KrasG12D mutat...

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Bibliographic Details
Main Authors: Martin F. Berthelsen, Siv L. Leknes, Maria Riedel, Mette A. Pedersen, Justin V. Joseph, Henrik Hager, Mikkel H. Vendelbo, Martin K. Thomsen
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
lung cancer
CRISPR
adenocarcinoma
mouse model
STK11
PTEN
Online Access:https://www.mdpi.com/2072-6694/13/5/974

Internet

https://www.mdpi.com/2072-6694/13/5/974

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